One of the things I value most about desktop computers is the very same reason so many people do without them: they take up a lot of space. That's a limitation in a society that trends toward studio apartments and a job market that promotes nomadism across the spectrum of professions that require computers — but for those of us who love PCs, it's the opposite: it gives us advantages and peace of mind. It defines our workspace, allows for more comfortable posture, and — inside the case — gives us room to install things, check how components are doing, and keep everything clean and organized easily.
I understand that for someone who has never opened a PC case, it might feel like having to repair an engine. But it's not — don't worry. With today's information, you'll be able to keep your PC in top shape, with no complications or risks — as long as you take basic precautions and don't go overboard playing engineer. I'll break things down into tasks to do every week and others that are fine to do two or three times a year. And all without any special tools.
Let's start with that, plus a disclaimer: if you're a pro gamer who needs specialized care for your PC, this guide clearly isn't for you. This guide is dedicated to the vast silent majority of people who move the world and make things happen from PCs with generic mice that cost next to nothing.
What you'll need
Cleaning a PC isn't expensive at all, though it does require two valuable things: time and space. The first few times, the weekly maintenance routine might take half an hour. But as you gain confidence, you'll get it done in just a few minutes.
The only essential tool is a Phillips screwdriver (the one with the + tip) for removing the case panels, expansion cards, and drives. You could clean the rest just by blowing on it, if you push me. There's no need to be that crude, of course, but no need to be fancy either.
Many guides like this one ask for microfiber cloths and anti-static brushes, compressed air cans, solutions of some kind of alcohol in demineralized distilled water, and other nonsense. It would be silly to say they're totally useless, but the truth is I've been cleaning my PCs for 25 years using hardware store paint brushes, orange chamois cloths, balloon inflators, cotton swabs, and tap water — and I've never broken or ruined anything.

Weekly tasks to clean and maintain your PC
Let's organize this by how often you should tackle each step. Unless you're an absolute slob, there's nothing that needs to be done daily. Grime, wear, and tangles only become noticeable after a week or a couple of weeks. So whenever you've got some free time, clear a table, gather the household tools mentioned above, and shut down and unplug your PC.
How to clean a monitor
Working with a keyboard that has a few crumbs won't wreck your hand, but always working with a stained monitor (spring sneeze splatters, stickiness from a Coca-Cola that was left too close) strains your eyes and looks terrible. Disconnect the monitor from the outlet and the PC case, and wipe it with a dry cloth. If you have anti-static microfiber, great. I use orange chamois cloths, which I try to keep clean. Even a piece of an old t-shirt works. Just make sure it's not the same rag you use for furniture polish or to clean your boots.
Slightly dampen a clean part of the same cloth (or grab another one) and make a top-to-bottom-to-top sweep of the monitor. Don't wipe in circles, and don't use alcohol or glass cleaner — they often have an overly soapy base. If a stain won't come off, go over the area with the cloth a bit more damp. Don't spray any product on the stains or try to remove them by scrubbing the screen hard. Cultivate the patience of a spider. Let it dry and pass another clean side of the cloth to pick up any lint.
How to clean a keyboard
Here you can be a bit rougher — the keyboard can take it. Unplug it and flip it upside down. A lot of the gunk will fall out on its own: homemade bread crumbs, ash, human hair or pet hair, seeds from some plant. For the rest, you'll need to give the base of the keyboard a few smacks. Hey, don't be afraid — I haven't broken any of the 20+ keyboards I estimate I've used by giving them a few slaps.
With that, the second-tier gunk should be gone, and you'll be left with some sticky dust, maybe a stray hair. Compressed air is overrated and expensive. So blow, just blow like there's no tomorrow — not straight at the keyboard but between the rows of keys. If you have a hand-pump balloon inflator, even better. If not, get one: for a couple of bucks you'll save yourself the dizziness of blowing too hard. And if the keys or the frame have sticky residue, you can use a damp cloth or remove the key and wash it (just make sure it's completely bone-dry before putting it back).
How to clean a mouse and its mousepad
For the mouse, you'll switch tools. Disconnect it and dust its grooves with a clean paint brush (half-inch ones from the hardware store cost next to nothing and are perfect). They'll tell you that you need an anti-static one. That's for snobs — don't listen to them. Grab a slightly damp cotton swab and try to remove dust, hair, or grime from the optical sensor (the red light underneath the mouse). If your mouse has a trackball, clean it using the same method. If you cleaned with anything damp, even if it was a miserable swab moistened with shower steam, wait for everything to dry before plugging the mouse back in.
On the other hand, that mouse won't stay clean or glide smoothly if the mousepad is a grease trap. Depending on what it's made of (the playmat-style ones like those for Magic: The Gathering, the plastic or silicone-coated ones), you can clean it with a small brush (and some dish soap if it's really greasy), or a damp cloth might be enough, or just a good shake.
How to clean headphones and speakers
If you use headphones, unplug them and/or turn them off (depending on whether they're wireless or wired — quite the symbol of the low tech high life). If they're over-ear headphones, use a clean cloth for the rigid parts. If they have cushions or foam with some synthetic covering, they've probably accumulated sweat or grease. It's inevitable — you're not dirty, you're human. Try to leave them as clean as possible after each use. Wipe the grease or sweat from the cushions with a dry lint-free cloth that's soft enough not to tear the padding.
If you use in-ear earbuds, clean the rubber tips and connectors with a cotton swab barely moistened with alcohol. Use another one, also dampened with isopropyl alcohol, to clean the charging station connectors if they're wireless. If they're wired, use a clean cloth slightly dampened with alcohol to wipe greasy residue off the cable. You should have done the same with the monitor, keyboard, and mouse cables, as well as the speaker cables.
If you use speakers, you don't need to deep-clean them every week, since they don't get as much contact as a keyboard or mouse (nor as many splatters as a monitor), but a quick wipe to remove dust won't hurt. Always be careful not to press too hard on the grille or the speaker cone.
How to clean game controllers
To clean your game controller, you need to unplug it or disconnect it from Bluetooth and turn it off — mainly so you don't accidentally trigger commands with the buttons. The surface cleaning is very straightforward: a cloth to remove dust, slightly dampened if the controller is really grimy, and the paint brush in the grooves, seams, and crevices. If there are very dirty spots, like the thumbstick buttons, use a cotton swab with isopropyl alcohol. It's also important to move the analog sticks around while cleaning the base, to remove dust from the mechanism and improve sensor performance.

Deep cleaning tasks to do a few times a year
How to deep-clean speakers
Since we were talking about audio peripherals and gaming, every now and then (a couple of times a year is fine) you need to turn off and disconnect the speakers from the PC to do more than just wipe the plastic or wooden part (the "enclosure") with a dry cloth. Now, let's look at a deeper cleaning. If the grille is removable, take it off and clean the inside with the balloon inflator. First, use your fingers to remove any clumps of hair or lint you can reach. You can also access the speaker's interior by fully or partially disassembling the enclosure on some models. Also check the connections (whether they're mini-jack or RCA), clean them of any obstructions (even the tiniest bit of lint you see), and clean the jacks with a cotton swab with a little alcohol.
How to open the case and remove the worst of the grime
Time to go inside the PC case. Remove the side panels (most people only take off the one opposite the motherboard, but remove both). First, inspect how everything looks. Taking a photo wouldn't be a bad idea. Then, use your fingers to pull out every big clump of lint you see. You can also flip the open case to let things fall out, but don't go smacking it around. If you see a mess of cables, carefully check where each one comes from and where it goes, and try to reorganize and replug them exactly as they were. Cable ties are a great help here, but be careful not to crush any cable. A few pumps from the balloon inflator can help you remove the bulk of the debris. You can use the paint brush on the metal parts of the case frame to sweep away dust. Your case should have lost 80-90% of its internal grime at this point.
As for the internal data and power cables, you can remove the dust from the cable bundles with the paint brush or a cloth, always making sure the grime you remove from one part doesn't settle on another part of the PC. Clean each thing as you go, then go back over everything and remove the debris. At the end of this process, don't forget to check that all internal cables are secure and in the right place (you'll clean their connectors as well).
How to clean fans
You should clean the fans among the first things, because they're some of the biggest dust and lint collectors. You don't need to dismount the fans from the case frame or side panels unless they're really jammed up or it's the first time in a long while that you're touching them. You'll be doing this with the PC off and unplugged, so you don't even need to disconnect them from their internal power headers. Hold the blades still with one finger so they don't spin, and with a clean, dry paint brush, make the necessary strokes to remove lint, grease, hair, and grime stuck to the blades. To finish, blow it out with your balloon inflator. Never, ever clean fans with damp cloths or apply liquid products. And don't even think about using the tip of a screwdriver to scrape off stuck-on gunk — the blades are balanced to spin at a certain angle, and you could throw them off. If you notice they make noise, vibrate, or wobble when spinning, you're going to need a new fan. They're not expensive and they greatly improve airflow (and noise levels) inside the PC.
How to clean the CPU and replace the thermal paste
You'll do the same job with the CPU cooler and heatsinks, dismounting them first if you can do it easily. If not, don't sweat it — some have certain clips that, if you get rough trying to remove them, you could snap. If it doesn't come off easily, don't force it. Removing the cooler mounted on the CPU will give you access to its heatsink and, beneath it, the CPU itself. If the heatsink is stuck to the CPU, gently twist it side to side before lifting it off. When you remove it, you'll have access to the CPU and you'll see the old, dried or hardened thermal paste.
Clean both the heatsink and the processor with a lint-free cloth barely dampened with a bit of isopropyl alcohol. When the CPU surface is clean and dry, place a pea-sized drop of fresh thermal paste in the center. You don't need to spread it with your finger or a card — when you put the heatsink back on and press down, the paste should spread on its own. Tighten the screws in a cross pattern, little by little, so the heatsink sits level — and consequently, so the fan sits level too. If this is misaligned, it won't just make noise — you could overheat and eventually burn out the CPU. When you're done, don't forget to plug the fan cable into the CPU_FAN header on the motherboard.
How to clean motherboards and graphics cards
When I say "boards," I'm generically referring to the graphics card (GPU), the motherboard, the memory modules, and potentially a sound card, network card, or something along those lines. If your case is spacious and organized, you wouldn't need to dismount anything. Even so, I like to dismount everything to clean it. At a minimum, unplug the thick bundles of power and data cables (remember where each one goes), and with the inflator, pump air evenly across the entire motherboard: between the memory modules, between the cables, and around the PCIe connectors. If you see areas where dust has caked up, use the paint brush or remove it with your fingers. Reinstall the memory modules and expansion cards.
The one that may need special care is the graphics card, which you'll definitely need to remove. First the screw on the back of the case, then check if there's some kind of latch or lever on the PCIe slot, and finally pull it out with a firm tug. Once it's out, you'll basically repeat what you did with the air blowing on the board (like with the motherboard) and the heatsink and fan cleaning (like with the CPU's). Some graphics cards may have thermal paste between the GPU chip (equivalent to the CPU) and its heatsink.
How to clean ports and connectors
As you work through everything in this guide, you'll constantly be unplugging things. That gives you access to the plugs and connectors — the "male and female" ends of every cable and board assembly. Take the opportunity to clean them, because connectors (USB, HDMI, audio, video, network, power supply) are contact points where dust, finger grease, and micro-debris accumulate, potentially causing false contacts or signal loss. Clean them using dry cotton swabs or ones barely dampened with isopropyl alcohol. Gently run them along the inner edge of each connector (never too deep) and let them dry briefly before plugging anything back in. Don't use napkins, tissues, or cotton balls, as they can leave residual fibers. For audio connectors (mini-jack or RCA), the ideal approach is to barely moisten the swab and twist it inside the jack with gentle movements.
If when reconnecting a cable you notice some "play" — the plug goes in loose — you may need to inspect the connector, the cable, or even the port. Depending on the degree of wear and what the problem is, you might just need to buy a new cable, or you may need to take the computer to a technician.
No choice but to get your hands dirty
That was the full walkthrough for cleaning, organizing, and maintaining the internal components and typical peripherals of a PC. Hopefully it helps you keep in the best possible shape that faithful companion you use to work, study, game, or get into pointless arguments on X. Everyone knows what they use their PC for. And now, thanks to 421, you also know exactly how to keep it looking sharp.